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AVM (Arteriovenous Malformation)
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Carotid and Vertebral Artery Dissection

Research and Clinical Trials

Neuroscience research at Carle Health represents the intersection of technology, medicine, science, and care. By providing our patients with the opportunity to participate in translational and clinical studies we hope to engage them in not only their own care but also the future of medicine. Our researchers and providers strive to advance diagnostic capabilities, understand causes and effects, and improve patient quality of life. Our research department supports clinicians and faculty alike in their efforts to provide excellent care and perform extraordinary science.

By participating in research studies, Carle Neuroscience Institute seeks to create a better understanding of the structure and function of neurological systems allowing us to advance clinical care possible and ultimately improve the overall promotion of human health and quality of life.

Carle Neuroscience Institute Research is known for demonstrating improved clinical outcomes for patients through research efforts that focus on the development of predictive analysis, novel diagnostics, and comparative efficacy.

OssDsign® Spine Registry Study ("Propel")

The purpose of this multi-center, prospective, observational registry is to gather information on the clinical outcomes and real-world use of commercially available bone graft substitutes manufactured by OssDsign® AB, in patients who require spine fusion.

Shift from unilateral to bilateral sensory-motor connectivity in chronic hemiparetic stroke

The purpose of this research study is to better understand how the movement and sensory pathways in the brain may be altered after a stroke.

Determine the effect of targeted high-definition tDCS on reducing post-stroke upper limb motor impairments

Significant motor impairments occur in 80% of individuals after moderate to severe stroke and impact the body side to the lesioned hemisphere. Typical motor impairments involve loss of dexterity with highly prevalent upper limb flexion synergy. Advances in treating flexion synergy impairments have been hampered by a lack of precision rehabilitation. Previous studies suggest and support the role of cortico-reticulospinal tract (CRST) hyperexcitability in post-stroke flexion synergy. CRST hyperexcitability is often caused by damage to the corticospinal tract (CST). We hypothesize that: 1) inhibiting the contralesional dorsal premotor cortex (cPMd) will directly reduce the CRST hyperexcitability and thus, reduce the expression of the flexion synergy; 2) facilitating the ipsilesional primary motor cortex (iM1) will improve the excitability of the damaged CST, therefore reducing the CRST hyperexcitability and the flexion synergy. we propose to use a novel targeted high-definition tDCS (THD-tDCS) to specifically modulate the targeted cortical regions for testing his hypothesis, via the following aims: Aim 1. Evaluate the effect of cathodal THD-tDCS over the cPMd on reducing the CRST hyperexcitability and the expression of flexion synergy. Aim 2. Evaluate the effect of anodal THD-tDCS over the iM1 on improving the excitability of the CST, and determine whether this, thus, also reduces the CRST hyperexcitability and the flexion synergy. Aim 3. Evaluate the confluence effect of bilateral THD-tDCS, i.e., simultaneous cathodal stimulation over the cPMd and anodal over the iM1.

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Meet Our Team

With doctors practicing in 80 specialties at locations throughout the region, it’s easy to find the right healthcare team at Carle. Our mission is to serve people through high quality care, medical research and education.

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Online Appointment Scheduling

Online scheduling is now available. Find the provider and time that’s right for you.

Giving

Charitable gifts are used for numerous projects and programs that enhance the healthcare experience for Carle patients and their loved ones. With your support, we’ll advance the care of neurological diseases and meet the needs of the 
ever-expanding Carle Neuroscience Institute.

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Awards and Accreditations

Recognized among the nation’s top hospitals, Carle provides excellent healthcare while continuously improving to meet the needs of our patients.

  • GL Accredited Hospital
  • Get with the guidelines - 2018 gold plus certified